Cellulitis is one of the most common skin and soft tissue bacterial infection which is a frequent cause of hospitalisation in adults. This increasing prevalence paved way for the study to primarily aim and assess the predisposing therapeutical and operational factors influencing the duration of antibiotic treatment regimen. Method: Prospective and observational study of 76 patients with cellulitis in their lower extremities admitted in government oriented tertiary care hospital. Patient demographics, social habits, comorbidities, complications, disease severity assessment through visual analogue scale, supportive laboratory and diagnostic parameters and treatment regimen were recorded with respect to hospital stay and analysed for their correlation in influencing treatment duration through SPSS software version 23. Results: Majority of the patients about 42.1% fell under 46-60 years of age category. There were 59.22% of patients with prolonged length of hospital stay receiving longer duration of treatment. The median value of number of days of hospitalisation was calculated to be 7 days with 3 to 10 as interquartile range. Age, CRP, ESR, neutrophils, type of wound, previous history of cellulitis, smoking along with comorbidity like diabetes and complications as DVT, Venous insufficiency were the variables independently significant with p value less than 0.05 with confidence interval of 95 %. Conclusion: The variables with significant p value showed association between treatment duration. Factors like antimicrobial medication choice, gender, causative micro organism showed negative response indicating no role in influence with treatment duration.