This research paper investigates the thermo-physical characteristics of a zinc oxide/graphene hybrid nanofluid and its impact on the performance of a ceramic-coated heat exchanger. The nanofluid is prepared by dispersing zinc oxide and graphene nanoparticles in a 50:50 mixture of ethylene glycol and distilled water. The thermal conductivity, viscosity, density, and specific heat capacity of the nanofluid are measured at various concentrations. Computational Fluid Dynamics (CFD) simulations are performed to analyze the heat exchanger's performance using the nanofluid. The results reveal that increasing nanoparticle concentration enhances thermal conductivity and viscosity while reducing specific heat capacity. The CFD analysis shows improved convective heat transfer and temperature distributions in the heat exchanger with the nanofluid. The findings demonstrate the potential of the zinc oxide/graphene nanofluid in enhancing heat transfer efficiency, which has implications for designing more efficient and cost-effective heat exchangers for various industrial applications.