Chronic kidney disease (CKD) has a major burden on worldwide health. CKD patients commonly manifested with a disorder of the thyroid hormones; though, the relationship is unclearly identified. Objective: assessment of the thyroid dysfunction among pre- dialysis CKD patients at Minia University Hospital. Methods: We analyzed data from the outpatient clinic of Nephrology & Urology at Minia University Hospital. 180 patients aged ≥ 18 years who had CKD at different stages except end- stage renal disease were included in this study and assessed for their renal and thyroid function. Results: There were significant differences in free thyroxine levels (FT3, FT4) and thyroid-stimulating hormone (TSH) among different stages of CKD (p=0.032, 0.037, 0.007 respectively). The percentage of stage IV CKD patients showed significant increase from (26.2%) euthyroidism to (54.2%) subclinical hypothyroidism (SCH) to reach (60%) overt hypothyroidism (p<0.004).There was a significant positive correlation between FT3 and FT4 with e GFR (P-value <0.0001, 0.003 respectively).While a significant negative correlation of TSH with eGFR (P-value <0.0001). Conclusion: that thyroid dysfunctions especially SCH and overt hypothyroidism were closely associated with pre-dialysis CKD patients.