The purpose of the study was to assess the levels heat shock protein 70 preoperatively, intraoperatively and postoperatively in patients with maxillofacial fracture. METHODS: This is a pilot study conducted on the patients admitted in Accident and Emergency Medicine of Sri Ramachandra institute of higher education and research from 2021 to 2023 with clinically and radiologically diagnosed facial fractures. In this study, specific serum sample were collected. The collection time included initial assessment – two hours after admission, second assessment – intraoperatively, final assessment – second day postoperatively. QUANTIFICATION: Venipuncture with withdrawal of 10 ml of blood for HSP70 quantification and kept for an interval of 15 -20 minutes for thorough coagulation. Centrifugation done at 3000 rpm for 15 minutes at room temperature. Samples will be aliquoted and stored at -80C until measurements. Quantification of hsp70 will be done through ELISA and values are assessed. RESULT: In this study we compared the HSP levels in control group with the study group. The result shows higher mean values in study group (intraoperative 41.0650 ng/ml > preoperative 35.9809ng/ml > postoperative 30.2492 ng/ml) compared to control group (27.7200 ng/ml). The comparison of mean difference of OD absorbance among the control and study group (preoperative) found p value of 0.028 implying statistical difference was seen among the control and preoperative group. CONCLUSION: Compared to healthy individuals and patients with isolated injuries, increased serum concentrations of HSP 70 were demonstrated. The present study provides the first in vitro evidence that the early release of HSP 70 protein into the bloodstream after injury was associated with a signi ficant increase in prognosis of traumatized patients