Propofol is one of the most popular IV anaesthetic induction drugs use for general anaesthesia, but it causes pain when given. The aim of this randomized control study is to compare the effects of pre anaesthetic single dose intravenous ketamine 100 mcg kg-1 and lidocaine 1 mg kg-1 for propofol induced pain. Methods: A total of sixty elective, normotensive adult patients were taken for this study. Study drugs either ketamine or lidocaine were given 15 sec before and then initially ¼ of the total calculated dose of propofol (2.5 mg kg-1) administered and a blinded anaesthesiologist asked the patient to rate any sensation of pain at 5,10,15 seconds till the patient was fully induced (after abolition of eye lash reflex). Pain during induction (At 5 sec, 10 sec, 15 sec). HR, SBP, DBP, SPO2 & ECG recordings before induction, during induction, intra operatively at 5min, 10min, 15min and post operatively and any other observations and side effects or complications were recorded and a P value < 0.005 was considered as statistically significant. Results: In our study out of 30 patients of each study group, 23 in group ketamine and 14 in group lidocaine did not have pain, 5 in group ketamine and 10 in group lidocaine had mild pain, 2 in group ketamine and 4 in group lidocaine had moderate pain, 0 in group ketamine and 2 in group lidocaine had severe pain. Median score was found 0 in group ketamine and 1 in group lidocaine. Conclusion: Ketamine 0.5 mg/kg in volume of 2 ml pre-treatment with venous occlusion is an effective method in reducing pain and providing hemodynamic stability after propofol induction than lidocaine 2 ml of 1%.