It was found that the drug discovery and development is a very time consuming and costly process. For reducing the time and cost Cadd is come. In thiswe have to discuss about the high-affinity ligands which inhibits the SARS-CoV-2.Some compounds docking score are good, but these are not considered because they cannot follow the Lipinski rule. Virtual screening involves the selection of specific drug candidates from the large library of various of chemical structures using the computational methods. When detecting the compounds with comparable shapes, ROCS uses a shapes-based position. In this study we must discuss what are the major cause for SARS-Cov-2 and how it can be resolve by using virtual screening.