Abstract- Local anaesthesia (LA) is widely used for medical procedures including maxillofacial surgeries. In 1948, lidocaine was the first local amide anaesthetic to be marketed and since then has become the “gold standard” against which other LAs are measured.1,2,3 Lidocaine in dentistry is used either as plain LA i.e. without vasoconstrictor or with vasoconstrictor. The commonly used vasoconstrictor is adrenaline. Its effects, systemic as well as local at the site of injection are well established. Aims & Objectives- The aim of this study was to quantitatively assess different hemodynamic parameters (SpO2, Heart Rate, Blood Pressure) during extraction under local anaesthesia at different concentrations of 1:80,000 and 1:2,00,000 with adrenaline. Material & Methods- This is a prospective, randomised controlled study. Patients who reported for extractions were included in the study. Hundred patients who satisfied the required criteria formed the study sample. Summary & Conclusion- The present study was conducted on a local population of sample size hundred evaluating their haemodynamic changes using pulse oximeter while administering lignocaine alone and lignocaine with adrenaline in different concentration of 1:80,000 and 1: 2,00,000 in otherwise healthy individuals. The present study comprises of two groups. Group I shows effect of lignocaine 2% with adrenaline 1:80,000 on blood pressure. In this group both systolic and diastolic blood pressure increases 100%