Background: Obesity causes phenotypic alterations in adipose tissue, which leads to chronic low- grade inflammation. Obese people are more likely to acquire several health-related problems most prevalent is Type 2 DM. Obesity is considered as a crucial pathogenic factor for Insulin Resistance (IR). TNF-α is a cytokine released as a result of phenotypic changes in adipose tissues. TNF-ꭤ involved in the pathogenesis of some inflammatory and autoimmune disease and proposed as a link between obesity and IR