Solanesol is a natural compound found in tobacco leaves, eggplants, and tomato plants. It has been reported to possess anti-inflammatory, anti-tumor, and anti-viral properties. In this study, Solanesol loaded gel was prepared using carbopol 940, propylene glycol, and distilled water. The gel was then evaluated for various parameters such as pH, viscosity, spreadability, drug content, and skin irritation. The results showed that the formulated gel for pH, viscosity and good spreadability. The drug content was found to be 98%, indicating that Solanesol was uniformly distributed in the gel. The skin irritation test showed that the gel was safe for topical application. The in vitro release study showed that the Solanesol gel had a sustained release pattern over a period of 8 hours. In conclusion, the formulated Solanesol gel showed sustained release and ideal physicochemical characterization, indicating its potential for use in the treatment of wound healing studies. Further studies are needed to evaluate its efficacy in humans.