Graph theory has provided chemists with a variety of useful tools, such as topological indices. A topological index Top(G) of a graph G is a number with the property that for every graph H isomorphic to G, Top(H ) = Top(G). In this paper, we compute ABC index, ABC4 index, Randic connectivity index, sum connectivity index, GA index, GA5 index, first Zagreb index, second Zagreb index, augmented Zagreb index, harmonic index and hyper Zagreb index of Cinoxacin.