The information provided discusses the potential benefits of transdermal patches as an alternative route of drug administration to overcome the side effects associated with the oral administration of Piroxicam (PXM). Transdermal patches allow for efficient systemic delivery of drugs by bypassing hepatic first-pass metabolism and continuously releasing the drug into the bloodstream through intact skin. The study highlights the development of transdermal patches containing PXM using the solvent casting technique, utilizing film-forming polymers like Hydroxypropyl Methylcellulose (HPMC) E50LV and Eudragit RS 100, along with glycerin as a plasticizer. Drug-excipient interaction studies using Fourier Transform Infrared Spectroscopy (FTIR) are conducted to ensure the compatibility and stability of the drug and patch components. The aim of developing transdermal patches is to improve drug delivery, minimize side effects