In those under the age of 45 all around the world, traumatic brain injury (TBI) is the leading cause of disability and death. Focusing on exterior, radiographic, autopsy, and histological exams with special focus to immunohistochemistry and molecular biology, this mini-review seeks to standardise the forensic method in neuropathological studies. Based on the findings of this brief review, a thorough forensic approach should be required whenever a suspected traumatic brain injury (TBI) of medico-legal significance is being investigated, with the goal of amassing as much evidence as possible to support the diagnosis of a lesion as the cause of death or a contributing factor in the cause of death. When various neuropathological disorders (ischemia, neurodegeneration, neuro-inflammation, dementia) could have contributed to mortality, only by following a process supported by evidence could a proper diagnosis be made. This is especially important when examining bodies in an advanced stage of decomposition, as radiological, macroscopic, and histological analyses often yield inconclusive results.