Quinoline, aryl-3,4-dihydropyrimidin-2(1H)-one (DHPMs) and 2-substituted quinazolin-4(3H)-ones, cephalosporin and 4-chloro-7-azaindole are of the most sought heterocycles for the development of new drug candidates. These rings can be traced in a number of well established, commercially available drugs. Wide array of pharmacological applications exhibited by these derivatives have made them obligatory anchors for the development of novel therapeutic agents. The current article herein highlights the synthesis of some miscellaneous quinoline derivatives with 2-substituted quinazolin-4(3H)-ones, aryl-3,4-dihydropyrimidin-2(1H)-one (DHPMs), cephalosporin and 4-chloro-7-azaindole linked-up with sulfonyl bridge. A series of diversified quinoline sulfonyl chloride devatives i.e. quinoline sulfonamides with 2-substituted quinazolin-4(3H)-ones, aryl-3,4-dihydropyrimidin-2(1H)-one (DHPMs), cephalosporin and 4-chloro-7-azaindole are synthesized and characterized using physical as well as spectroscopic techniques.