Through the exact change of live creatures' genetic makeup, genome editing technologies have revolutionised the area of biomedicine. CRISPR-Cas9 has distinguished itself among these technologies as a potent tool with enormous potential for modelling diseases and discovering new drugs. The use of CRISPR-Cas9 in biomedical research is examined in this work, with a particular emphasis on how it might be used to produce new drugs and model diseases. We go over the CRISPR-Cas9 tenets, why it's better than other genome editing techniques, and how it's been used successfully to treat various diseases in various disease models. We also emphasise how CRISPR-Cas9 has accelerated the identification of fresh therapeutic targets and the creation of more potent medications. We also talk about the problems and moral issues that CRISPR-Cas9 technology raises, putting a focus on its proper and moral application. Overall, this study highlights the important contributions of CRISPR-Cas9 to disease modelling and medication discovery, highlighting its potential to fundamentally alter the area of biomedicine.