The current study analysed the fruit pulp of ethanol extract of Annona squamosa that diminish AlCl3-induced behavioural, metabolic, and neurochemical changes that match symptoms of Alzheimer's disease (AD). Materials and Methods: Various behavioural and biochemical parameters that were carried out to evaluate the activity of fruit pulp of ethanol extract of Annona squamosa (FEAS) on AlCl3 intoxicated rats. To determine the therapeutic significance of FEAS on AD, different behavioural tests such as Morri’s water maze test, passive avoidance test and some biochemical tests along with neurochemical findings were done. Results: AlCl3 caused physical and behavioural deformity in animals, including abnormal posture, weak grip strength, and motor deficit. Biochemical analysis in brain homogenates of FEAS treated rats showed modified oxidative stress and raised lipid biomarkers. Neurochemical alterations of the striatum of FEAS treated rats exhibit altered levels of catecholamines. FEAS treated for 90 days significantly enhanced motor function and behaviour tasks and further restored the invitro antioxidant changes in the brain. Furthermore, FEAS-II treatment significantly improved oxidative damage, which is denoted by the alterations in neurochemical changes of rat brain. Conclusion: In this experimentation, FEAS-I & II (200 mg/kg & 400 mg/kg) provided a remarkable neuroprotective impact, which was evidenced by behavioural and biochemical tests. It recovered the behavioural and biochemical alterations caused by AlCl3 and authenticated the strong neuroprotective mechanism of FEAS in AlCl3-intoxicated behaviour and motor abnormalities.