This research paper focuses on the synthesis and anti-cancer evaluation of novel curcumin derivatives. Curcumin, a natural polyphenol, possesses promising anti-cancer properties, but its clinical application is limited. The synthesis of novel derivatives aims to overcome these limitations and expand the horizons of cancer therapy. Through structural modifications and optimization strategies, these derivatives exhibit improved potency, selectivity towards cancer cells, and reduced toxicity compared to the parent compound. In vitro and in vivo evaluations demonstrate enhanced anti-cancer activity, paving the way for further development and potential clinical translation. These novel curcumin derivatives offer new avenues for targeted cancer therapy and improved patient outcomes.