The objective of this study was to assess the effectiveness of upper gastrointestinal (GI) endoscopy performed by general surgeons as a diagnostic tool, based on an analysis of 200 cases. Methods: We retrospectively reviewed 200 cases where upper GI endoscopy was performed by general surgeons at our institution from 2021 to 2022. The main variables evaluated were diagnostic yield, procedural complications, and patient satisfaction. Results: In the study involving upper GI endoscopies conducted by general surgeons, 85% of the cases showed no complications. However, complications did arise in 15% of the procedures, with the most frequent being mild bleeding at 7.5%. When evaluating patient satisfaction through a standardized questionnaire, patients reflected a high satisfaction rate. Conclusion: This study suggests that upper GI endoscopy performed by general surgeons is an effective diagnostic tool, evidenced by a high diagnostic yield, low rate of complications, and high patient satisfaction. However, further large-scale studies are recommended to confirm these findings and to compare the outcomes of upper GI endoscopy performed by general surgeons versus gastroenterologists