Elevated liver enzymes is common in patient infected with COVID-19 and recent cohorts found that it present in 17% - 57% of COVID-19 patients. Transient elastography (TE) is a widely used non-invasive tool to measure liver stiffness (LS). LS measurements are a sensitive method to detect liver damage, and increased LS values are seen in compromised liver tissue like in chronic and in acute hepatitis(1). Aim and objectives: To identify the validity of liver transient elastography in assessing the severity of disease in COVID-19 patients. Subjects and methods: This was a prospective observational cohort study that included patients hospitalized due to covid-19 infection documented by reverse transcription polymerase chain reaction (PCR) to kasr el-Ainy isolation unit during the period from June 2021 To March 2023. Results: there was a statistically significant difference between the studied groups regarding , liver biomarkers(ALT, AST, LDH, ALK and LDH), inflammatory biomarkers, oxygenation, Length of hospital stay, SOFA score and Mortality. Conclusion: Transient elastography is a useful and non-invasive tool to assess onset and severity of acute liver injury in patients with COVID-19 patients. Increased LS seems to be predictive for a more severe and complicated course of disease.