Rizatriptan benzoate is the potent drug molecule for the treatment of the migraine. Wet Granulation Technique was used for development of Orodispersible tablets of Rizatriptan Benzoate to enhance the flow properties of the granules during compression. For granulation, IPA was selected and two different types of the superdisintegrants were used for the formulation such as SSG and Crospovidone. Apart from these, Dioctyl Sodium Sulphosuccinate was also used in the formulation. Diluents used were MCC pH 101 and MCC pH 102. Aspartame was used as sweetening agent, Colloidal Silicon dioxide was used as Glidiant and Sodium Stearyl Fumarate was used as Lubricating agent. Total Nine formulations from F1 to F9 were designed and concentration of two Superdisintegrants was varied keeping the concentration of other excipients constant. Three different concentration of SSG i.e. 26 mg per tab, 10 mg per tab and 18 mg per tab were used. Also three different concentration of Crospovidone i.e. 9 mg per tab, 15 mg per tab and 12 mg per tab were used. DOSS was used as 0.1 mg per tab in formulations from F5 to F9 and DOSS was not used in remaining formulations. Prepared Orodispersible tablets were analyzed for different In-Vitro parameters such as Physical Description, Average weight, Tablet’s Hardness, Tablet’s thickness, Moisture content, Friability, Time of Disintegration, Assay%, Dissolution% and Uniformity of content. Formulation number F5 was determined as best formulation with disintegration time of 12 seconds and Dissolution value of 99.53% whereas formulation number F3 was comparatively less beneficial with disintegration time of 56 seconds and Dissolution of 86.17%.Concentration of the Superdisintegrants mainly showed its effect in dissolution and Disintegration value where as others parameters were not subjected for significant changes. For the formulation of Orodispersible tablet of Rizatriptan benzoate, DOSS can be used in lower concentration for decreasing the disintegration time and for having higher dissolution %. Similarly SSG should be used at intermediate concentration and Crospovidone at higher concentration. Synergistic combination of them plays crucial role for having the optimum value of disintegration and dissolution value