The viral diseases are the greatest threat to the human health. Although numerous anti-viral agents are available commercially yet they are not potent against the wide continuum of viruses. Thus, it becomes essential to move back to our mother nature for the solution. The common traditional drug – Giloy obtained from Tinospora cordifolia so recognized as Guduchi, heart leaved moon seed as well as Gurjo is mentioned in ancient Indian literature which is used against many diseases. It possesses a diversity of phytoconstituents for instance alkaloids, glycosides, steroidal compounds, lactones, terpenoids, polysaccharides which are responsible for the various pharmacological effects viz. antidiabetic, anticancer, antimicrobial, anti-inflammatory, anti-psychiatric, antihypertensive, immunomodulatory, vasorelaxant, and anti-viral action. The anti-viral effect of this plant has piqued the interest of experts in recent years. The current investigation targeted to explore the anti-viral potency of the individual phytoconstituents of Guduchi through in silico studies. The PASS online (Prediction of Activity Spectra for Substances) means was used to forecast the anti-viral effect. Even the antiviral potential of each individual phytoconstituent against a variety of viruses was also evaluated. The physicochemical properties, pharmacokinetics, drug-likeliness, medicinal chemistry friendliness and adverse effects of these phytocompounds were also investigated through the in-silico techniques. The findings of the study may be used by the upcoming researchers in the streams of phytochemistry, pharmacology and ethnobotany for the purposes of drug discovery. Yet, a more exhaustive exploration at molecular and cellular levels is required. To establish the anti-viral prospective of these phytomolecules, suitable in vitro and in vivo models need to be established and finally the clinical studies are essential to illuminate the anti-viral potential of the drug.