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ISSN 2063-5346
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UV SPECTROSCOPY ESTIMATION OF AMBROXOL HCL AND COMPARISON OF THEIR DISSOLUTION PROFILES

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Sushil D. Patil , Reena Sharma , Virendra Kumar Patel , Kuldeep Shukla , Sayyad Tamanna Dilkhush , Sunil V. Amrutkar , Ramanlal N. Kachave
» doi: 10.48047/ecb/2023.12.si6.521

Abstract

Ambroxol Hydrochloride is a commonly used medication that is available in multiple varieties, making it difficult to choose the safest and most effective one. Therefore, the purpose of this study is to establish the pharmaceutical equivalence of the various brands of Ambroxol Hydrochloride tablets and to validate the quality of the various brands on the market. The study involves the quantitative analysis of ten different brands of Ambroxol Hydrochloride 30 mg tablets using Ultra Violet Spectrophotometric methods, in which the samples were dissolved in distilled water and their absorbances were measured at a wavelength (max) of 243 nm. Quantitative determination of Ambroxol Hydrochloride by UV-Visible Spectrophotometric methods, utilizing standard absorptivity value (assay method described in the Indian Pharmacopoeia) and calibration curve method. The percentage content of each sample was determined using both methods and the appropriate formulas, as well as whether or not the samples complied with IP standard specifications. Using the IP Method, the percentage of Ambroxol Hydrochloride in various brands of Ambroxol Hydrochloride tablets was compared. In addition, the IP method and Calibration curve method outcomes were compared.

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