Although vaccination has proven to be one of the most effective public health measures, vaccine acceptance rates vary across the world. Vaccine hesitancy is a complex multifactorial problem that faces communities and hinders their efforts to reach herd immunity. It was listed in 2019 by the World Health Organization as one of the top ten global threats. Later on, The COVID-19 pandemic has shed more light on the problem and its bad effects. Multisectoral approaches involving all the related stakeholders are needed to target the determinants of vaccine hesitancy and reduce its bad effects on both individuals and communities.