Background: The Lymphedema Quality of Life Questionnaire, which has four components (function, appearance, symptoms, and mood) and final score, was created to assess the quality of life for lymphedema patients. It is accessible in many different languages. Aim of the study: This study was carried out to examine the psychometric features of the translated Arabic version of the lymphedema quality of life questionnaire and to validate it. Methods: The Arabic LYMQOLQ-UL/LL was acquired using the forward-backward translation method between June 2022 and August 2022. Patients were chosen from the National Cancer Institute of Egypt, the National Cancer Institute of Tanta, and the hospital of health insurance-El Gharbia. In this study, ten specialists and 100 patients with a mean age of (48.11 6.97) years each participated. Reliability was examined using internal consistency analysis and test-retest procedures. Test-retest analysis was conducted using the intraclass correlation coefficient (95% confidence interval), and internal consistency was assessed using the Cronbach alpha value. Index of clarity was used to detect the LYMQOLQ's face validity, and the scale (CVI) was used to assess the LYMQOLQ's content validity (S-CVI). By looking at the association between LYMQOL and the EORTC QLQ-C30, internal construct validity was evaluated.