Introduction: Cancer remains a life threatening disease and affects almost all age groups. Cancer usually arise as the result of lifestyle changes (tobacco, smoking and alcohol abuse) , bacteria, viruses and other environmental factors. Oral Squamous Cell Carcinoma (OSCC) occurs mainly due to the accumulation of numerous genetic alterations in squamous cells of the oral cavity. Lack of awareness and poor prognosis are the main reason for higher incidence of OSCC. Numerous experimental and clinical data reveals that tumour growth and metastasis are associated with new blood vessel formation (Angiogenesis). Vascular Endothelial Growth Factor(VEGF) is the most important factor involved in angiogenesis which is mainly involved in tumour induced angiogenesis.