Background: Cirrhosis is defined as the histological development of regenerative nodules surrounded by fibrous bands in response to chronic liver injury, that leads to portal hypertension and end stage liver disease. Recent advances in the understanding of the natural history and pathophysiology of cirrhosis, and in treatment of its complications, resulting in improved management, quality of life and life expectancy of cirrhotic patients. Vitamin D deficiency has been defined as serum 25(OH)D levels lower than 20 ng/mL (i.e. 50 nmol/L) and vitamin D insufficiency has been defined as serum levels between 20 and 30 ng/mL (i.e. 50-75nmol/L). According to the Institute of Medicine (IOM) of the National Academies in the United States, vitamin D concentration of 20 ng/mL is adequate. However, the Endocrine Society (Maryland, USA) recommends levels of at least 30 ng/mL (i.e. 75 nmol/L) as adequate and concentrations between 40 and 60 ng/mL (i.e. 100-150 nmol/L) as optimal. Th ere is still no definition regarding the optimal vitamin D levels for patients with chronic liver diseases. Vitamin D insufficiency and deficiency are considered to be common in the general population and more frequent among elderly people and individuals with chronic diseases. It has been reported that 1 billion people have inadequate serum levels of 25(OH)D levels. However, the normal range of vitamin D levels has been debated. In general, optimal vitamin D status ranges from 30 to 50 ng/mL (i.e. 75-125 nmol/L). Muscle cramps in this patient population are a usual and high event (88%). With an electromyogram, the activation of involuntary potential action of the motor units was rather high, over 150 Hz. The behaviour of the peripheral nervous system is not connected to nerve degeneration. The cause that supports the presence of cramps remains inconclusive. The presence of cramps varies depending on the muscle area: cervical (9%), thigh (43%), calf (70%), toe (50%), abdominal muscles (12%), and fingers (74%). More areas of the body can be affected. No direct relationship is established between age or specific causes that lead to cirrhosis (alcohol, infection, etc.). No connectable cause or specific treatments are known to avoid the onset of cramps in patients with cirrhosis.