Background: Obesity is associated with bronchial asthma, and asthma greatly restricts the patient’s activity, which predispose to obesity. However, the possible pathogenic mechanisms had not been fully understood. Vitamin-D deficiency is associated with obesity and asthma. However, its values in obesity-associated asthma did not fully explored. The current work designed to estimate the serum levels of vitamin-D, some interleukins in obese and non-obese subjects with and without asthma.