T2DM is a disease of multifactorial etiologies caused by insulin resistance and impaired insulin secretion. Increasing evidence indicates that genetic factors contribute to T2DM susceptibility. Evidence from various studies suggest that vitamin D receptor (VDR) gene polymorphisms are associated with type 2 diabetes (T2D); However, these results have been disputable. Aim; in this article we aimed to present Vitamin D receptor Cdx2 polymorphism in non-insulin dependent diabetic patients, Methods: We performed a search of MEDLINE through PubMed and Web of Science [Science Citation Index Expanded, SCI-EXPANDED), Social Sciences Citation Index (SSCI), and Emerging Sources Citation Index (ESCI)] of all scientific literature published from May 2020 until April 2023, Summary; Numerous studies disclosed the independent role of VDR genetic polymorphisms involved in pathogenesies of various metabolic disorders like type 2 diabetes mellitus in different populations, Such interlationshipis involvedcomplex inheritance pattern.The polymorphisms of various genes including vitamin D receptor (VDR) might affect genetic susceptibility of T2DM by developing malfunctioning of beta pancreatic cells or insulin resistance. Geneticarchitecture of T2DM is different among various ethnic populations.