Background: Vitamin D is known for its potential anti-inflammatory effect in inflammatory diseases such as bronchial asthma. Thus, vitamin D receptor gene polymorphism may contribute to genetic susceptibility to asthma. There is a paucity of knowledge on vitamin D receptors, single nucleotide polymorphism (SNP) in Egyptian asthmatic children. Methods: We enrolled children; aged from 2-12 years; 100 asthmatic and 100 healthy. They were investigated using a complete blood picture, total serum IgE level, and DNA analysis using PCR RFLP technique for identification and analysis of SNP, FokI (rs 2228570), and BsmI (rs 1544410). Results: Analysis of possible genetic models showed a significant difference between cases and control in the recessive model of FokI SNP (Ff & ff), (p=0.04), as well as the (f) allele (p=0.02). On the other hand, genotypes and allele frequencies of BsmI SNP were not significantly different between asthmatic children and control (P=0.24 & 0.35 respectively). Both SNPs were not significantly different among the three groups of asthma severity (mild, moderate, and severe persistent). Conclusions: The recessive model of FokI SNP (Ff & ff), as well as the presence of the f allele, were independently associated with an increased risk of asthma in Egyptian children.