Vitiligo is one of the most common diseases, but it causes the colored spots on a human body to distinguish the patient from other medical conditions and lead to a derangement of the patient's mental state. Such a situation hinders the complete recovery of the patient and increases the power to aggravate the disease. The role of mental health in improving the quality of life of vitiligo patients is huge. This study attempt to examine, how a vitiligo patient's self-esteem and quality of life influence their disease progression and recovery.