Cancer is one of the leading causes of death worldwide. Mortality rate from cancer can be reduced when the cases are diagnosed early. Due to poor prognosis and lack of any method for early detection of cancer, volatile organic compounds (VOCs) have been used as a non-invasive and screening tool for detection of cancer. An online literature search was conducted to identify studies reporting VOCs in various body fluids like breath, urine and blood. Results: VOCs are specific for each cancer type with limited cross over. The types of cancer which have been considered are urinary bladder, prostate, colorectal, breast. TP53 gene has been shown to be the most mutated gene. Conclusion: Various studies have shown that VOCs in different fluids can be detected by non-invasive method by using breath analysis. However, large clinical trials are required for better pharmacological intervention.