Background: Workplace violence (WPV) against emergency nurses is a prevalent global issue, with verbal abuse being the most common form of aggression experienced by healthcare workers. Nurses are at a higher risk of violence due to direct patient care responsibilities and inadequate training in managing volatile situations. The impact of violence on nurses' job performance, satisfaction, and retention is significant, with implications for the healthcare sector's workforce stability, particularly in countries like Saudi Arabia facing a growing demand for nursing professionals. Objective: This review aims to assess the prevalence and types of workplace violence experienced by nurses in healthcare settings, explore the sources of violence, examine its effects on nurses' physical and mental health, job satisfaction, and retention, and evaluate the effectiveness of current prevention strategies while identifying areas for improvement. Conclusion: Workplace violence against nurses in emergency departments is a complex issue influenced by various factors such as high-stress environments, inadequate resources, and patient-related triggers. The consequences of violence extend beyond physical injuries to emotional and professional repercussions, highlighting the urgent need for comprehensive prevention programs. Management commitment, worksite analysis, and hazard prevention and control measures are essential in mitigating workplace violence and ensuring the safety and well-being of healthcare workers. By prioritizing the development and implementation of effective prevention strategies, healthcare organizations can create safer environments for nurses and enhance patient care quality. Addressing workplace violence is crucial for maintaining a sustainable healthcare workforce and promoting a culture of safety and respect in healthcare settings.