Background: Early identification and disease monitoring of secondary osteoporosis(OP)in rheumatoid arthritis (RA) are challenges for rheumatologists, identification of biomarkers predictive to bone mineral density (BMD) change is crucial in management. Serum14-3-3η protein is validated as a diagnostic and prognostic biomarker in RA. Meanwhilethe exact mechanism by which 14-3-3η intervenes osteoporosis is still unclear and few studies have been focused on it. Our aim wasto evaluate the association among 14-3-3η protein, inflammation, bone remodeling, osteoporosis riskand disease activity in RApatients.