The Objectives of this is study is to assess the NICU stressors and attitude among the mothersof sick neonates in SRM General Hospital. The research approach was quantitative research approach and the research design adopted was Non Experimental correlational research design. The mothers of neonate admitted to the NICU were selected by non probability convenient sampling technique. The sample size for the study was 70. The data was collected using standardized tool - Parental Stressor Scale (PSS: NICU), the attitude scale lists the various attitude of a mother that arises during the hospitalization of a sick newborn which was preparedby the investigator. Twenty (20) minutes was spent to elicit data from each participant. Following data collection a learning module on NICU Stressors and coping management was given to the mothers of sick neonates. The analysis reveals that, majority of the mothers 50 (71.4%) experienced severe stress whose neonates were admitted in NICU. The overall level of attitude among the mothers of sick neonates, 64 (91.4%) of the mothers had Moderately Favourable Attitude. The subscale namely “baby looks and behaves” has the mean value 75.20with standard deviation + 4.52 had the highest levels of stress. It is evident that there is statistically significant negative correlation (r= -0.724) between Stress and Attitude p < 0.05. Therefore, there is a need for interventional program to help the mothers to adapt to the hospitalization of the neonates to overcome the stress.