The process of meta-analysis and systematic evaluation of randomized controlled trials focused to measure the effects of consumption of the mulberry consumption on the cardiometabolic risk sectors. Mulberry supplementation was found to noticeably lower fasting levels of blood glucose, hemoglobin A1c, total cholesterol, and the triglycerides. This systematic review and meta-analysis aimed to assess the effects of consumption of mulberry on cardiometabolic risk factors. A comprehensive search was conducted in various electronic databases for randomized controlled trials inspecting the effect of mulberry intake Mulberry consumption was also associated with an increase in HDL cholesterol levels. These findings suggest that mulberry supplementation may be advantageous to cardiometabolic health and could be a potential dietary intervention for individuals with metabolic disorders. Finally, The outcomes of the systematic review and meta-analysis suggest that the mulberry consumption may benefit cardiometabolic risk factors .Mulberry supplementation may be a potential dietary intervention for individuals with metabolic disorders. The best mulberry supplementation dosage and time frame should be determined through further study, as well as any potential long-term impacts.