A HPLC method was developed and validated of Montelukast Sodium and Bilastine in bulk formulation. The chromatographic separation of drug was achieved on 29/05/2021. The mobile phase consisted of Acetonitrile and Buffer (70:30), The flow rate was adjusted to 1.5 ml/min. and %RSD as 0.0013. This proposed method is accurate, highly sensitive and precise which helps in cost reduction of analysis, hence we can use it for routine quality analysis in laboratories.