A medicinal herb known as Andrographis paniculata (A. paniculata) is used in both Indian and Chinese traditional medicine for a variety of therapeutic benefits. This is caused by the presence of "Andrographolide," a diterpene lactone. Andrographolide and its natural counterparts are thought to have a number of biological functions, including anti-inflammatory, anti-tumor, anti-hyperglycaemic, anti-fertility, antiviral, cardiac protecting, and hepatoprotective qualities. Studies have revealed the presence of more closely comparable terpenoid analogues from A. paniculate in addition to this diterpene lactone (Andrographolide): This investigation focuses on Andrographolide, a diterpenoid molecule from Andrographis paniculata, which has anti-inflammatory properties. Studies examined the effects of Andrographolide and the characteristics of the target, with a focus on transcription factors. NF-kappaR The DNA binding region, or active site, of NF-kappaB, is discovered to have primarily positive potential. Negative potency is required for a specific inhibitor to have electrostatic complementarity. This substance inhibits the activation of NF-kappaB and reduces the expression of inducible nitric oxide synthase (iNOS), among other anti-inflammatory effects. Additionally, it stops human neutrophils from producing oxygen radicals and stops human fibroblast cells from expressing COX-2.