The present study Methanol extract of Pithecellobium dulce Leaves were prepared using Maceration method. The extracts were evaluated for antibacterial activity against The need for search for new Herbal Drug therapy for Microbial Infections has therefore become a constant, exercise to Staphylococcus aureus (Gram +ve) Escherichia coli (Gram -ve) Staphylococcus epidermidis (Gram +ve) Bacillus subtilis (Gram +ve) Bacillus cereus (Gram +ve)Disc diffusion method open auspicious antibacterial activity of the extracts prepared in polar solvents methanol Leaves extract was found to be most active against Microbial strains. The antibacterial activity of Pithecellobium dulce L. leaves methanolic leaves extract was found to be effective against all the five tested Bacterial strains. These findings suggest that methanolic leaves extracts of Pithecellobium dulce has potential as effective anti-bacterial agent