In the wake of global health crises stemming from infectious diseases, forensic and mortuary services face unprecedented challenges in managing fatalities. These departments play a pivotal role in public health and safety, necessitating the development of robust strategies to handle the complexities of infectious disease fatalities. This critical analysis delves into the multifaceted challenges encountered, including biohazard risks, resource constraints, logistical complexities, legal and ethical considerations, and the psychological impact on staff. It further explores current strategies and solutions implemented to mitigate these challenges, such as enhanced safety protocols, specialized training programs, technological advancements, interdepartmental collaboration, and support systems for staff well-being. Through a synthesis of literature and case studies, this article highlights the effectiveness of these strategies and proposes recommendations for future preparedness and response efforts. The ultimate goal is to enhance the capacity of forensic and mortuary services to manage infectious disease fatalities efficiently, safely, and with dignity, thereby reinforcing public health infrastructure in the face of future outbreaks.