To determine the physiologic changes in the salivary pH and salivary buffer capacity in patients undergoing fixed orthodontic treatment. Materials and Methods: The study included 70 patients scheduled for fixed orthodontic therapy. Unstimulated saliva samples were taken before placement of the appliance(T0) and at 1 month (T1),3 months(T2) and 6 months(T3) during the therapy. Saliva-Check BUFFER kit from GC India Dental Pvt Ltd, India was used to check salivary pH and buffer capacity at these time periods. Results: No statistically significant difference was seen in pH values between the different time periods. No significant difference in the buffering capacity was seen between T0 and T1, but a statistically significant difference is present between the values at T0 and T2 as well as T0 and T3. Even the values at T1 were significantly different fom T2 and T3. Conclusion: Orthodontic treatment changes the oral environmental factors and promotes an increase in buffer capacity of the saliva which increases the anticaries activity of saliva.