Removable dentures are most widely used to replace missing tooth. Poly methyl Methacrylate (PMMA) is the commonly used material to fabricate denture base by heat cure technique. It has the advantage of low cost, a simple fabrication process, light weight, satisfactory aesthetics, colour matching ability and easy to do finishing and polishing. However, it has certain disadvantages like insufficient surface hardness, low strength in thin sections and brittle in nature. Glass nanoparticles and Carbon nanotubes have shown, to have increased strength when used in other various forms in dentistry. In this study, the impact strength of Non-reinforced PMMA denture base material are compared with reinforced PMMA (Glass nanoparticles and Carbon nanotubes). Materials and methods: A metal block of dimensions 60mm x 12mm x 3mm(following ASTM standards) were used to form the mould space for acrylisation of samples.2 For the control specimen non-reinforced PMMA material were used with standard powder to liquid ratio as per manufacturer’s instructions. For Glass Fibre specimens (20-80nm Nanoparticles), the heat cure polymer powder (Dpi) were mixed with Glass Fibres of 5% by weight. For Carbon Fibre specimens (2-10m Nanotubes), the heat cure polymer powder (Dpi) were mixed with Carbon Fibres of 5% by weight. The specimens were then flasked and cured by water bath polymerisation method. Following which, the samples were finished and subjected to IZOD type of impact tester using CEAST impact tester.