The aim of the present study was to develop a tablet formulation based on flurbiprofen-cyclodextrin system that allows rapid and complete dissolution of Flurbiprofen an insoluble drug practically. For the development of tablets, three different cyclodextrins: the parent β-cyclodextrin and two amorphous derivatives i.e., methyl-β-cyclodextrin and hydroxyethyl-β-cyclodextrin were evaluated. Equimolar drug-cyclodextrin binary systems were prepared according to five different techniques i.e., physical mixing, kneading,sealed-heating, coevaporation, and colyophilization. All these binary systems were characterized by Differential Scanning Calorimetry, x-ray powder diffractometry, infrared spectroscopy, and optical microscopy and evaluated for solubility and dissolution rate properties. The drug solubility improvement observed in the different binary systems varied from a minimum of 2.5 times up to a maximum of 120 times, depending on the type of cyclodextrin and the preparation method employed. Tablets were prepared suing direct compression method employing the selected binary systems. Chitosan and spray-dried lactose, were used as excipients in the formulation. All formulations containing drug-cyclodextrin systems showed greater dissolution compared to the drug alone. However, the drug dissolution behavior of the drug-cyclodextrin system was strongly influenced by the formulation factors. Tablets containing the drug mixed with methyl-β-cyclodextrin or colyophilized with β-cyclodextrin and spray-dried lactose satisfied the requirements laid down by the Food and Drug Administration (FDA) for fast dissolving tablets.