1, 3, 4- Thiadiazole is one of the heterocyclic compounds having different versatile activities such as anti-diabetic, anti-microbial, anti-convulsant, anti-inflammatory and anti-cancer. A new 1,3,4-Thiadiazole derivatives with Schiff base compound synthesized. The starting material N-(4-chlorophenyl)hydrazine carbothiamide synthesized by the reaction between aniline derivativesand carbondisulfide, hydrazine hydrate followed by synthesis of 5-(4-aminophenyl)-N-(4-chlorophenyl)-1,3,4-thiadiazole-2-amine. The chemical structures were confirmed by the elemental analysis IR, UV and H1 NMR and Thin layer chromatography and perform pharmaceutical activity carried out against S aureus,E Coli, K. Pneumonia, M luteus and candida albicans and compared with the standards from which 4-NO2, 4-Cl, 2-OH,-H derivatives shown promising antibacterial activity and 4-Cl derivative shown promising anti-fungal activity.