Internal stabilization has become a popular approach for treating spine injuries and diseases, but aseptic instability of stabilizing system components remains a significant concern. This study aims to address this challenge by developing and implementing titanium implants with a novel therapeutic effect, incorporating a calcium phosphate coating for spinal fixation. A comprehensive study involving 1810 stabilizing operations was conducted, and the occurrence of aseptic instability was analyzed. Factors contributing to instability, such as osteopenia and non-compliance with exercise regimens, were identified. The study highlights the importance of specialized surface treatment and the potential of calcium phosphate coatings to improve osseointegration. The fabrication process of the experimental implants with calcium phosphate coatings is described. Clinical trials of these implants are planned to assess their effectiveness and safety. The findings of this research contribute to improving the outcomes of spine stabilization procedures and have implications for domestic implant manufacturers.