This article presents an analysis of the overall prevalence of mental disorders and disability associated with these disorders. In recent years, the establishment and adoption of the biopsychosocial model in psychiatry as a necessary approach to healthcare delivery has become evident. The findings of this study will aid in the planning and implementation of organizational measures aimed at improving the quality of healthcare services in this field. The aim of the research was to conduct an analysis of disability due to mental disorders in the Republic of Uzbekistan during the period from 2018 to 2022. Materials and Methods: The analysis of overall morbidity and disability due to mental disorders was conducted based on retrospective data obtained from the state statistical reports on primary and overall prevalence of mental disorders and disability associated with them during the period from 2018 to 2022. Results: The conducted research demonstrates a consistent trend of decreasing prevalence rates of overall mental disorders in the Republic of Uzbekistan. In 2018, the rate per 100,000 population was 1036.3, whereas in 2022, it decreased to 752.0. These findings highlight the success of measures taken in the field of mental health and healthcare provision in the country. The results contribute to the understanding and planning of future strategies to further improve the mental health services and disability management in the Republic of Uzbekistan.