Periodontitis is characterized by microbially-associated, host-mediated inflammation that results in loss of periodontal attachment.Numerous risk factors are involved for progression of periodontal disease like uncontrolled diabetes, smoking, age, psychosocial stress and certain psychosomatic conditions like anxiety and depression. Stress is a state of physiological or psychological strain caused by adverse stimuli, physical, mental, or emotional, internal or external, that tend to disturb the functioning of an organism. Stress has a direct effect on the hypothalamus-pituitary adrenal cortex axis. Many studies have demonstrated a correlation between stress and an increased risk of developing periodontal disease and clinical attachment loss.Release of stress hormones (cortisol) impairs host defense which helps in the growth of opportunistic organisms in the gingival sulcus.