Background: There are various pharmacological activities associated with benzoxazole, and alterations in the nucleus of benzoxazole have resulted in a number of compounds that have differing pharmacological properties. Triazole may be added to it to explore potential central nervous system (CNS) activities. There is potential for an antiepileptic effect with the triazole substituted benzoxazole derivative (TSBD) tested in this study. Biologically active compounds are prepared by focusing on the construction of molecules that are biologically active. Methods: The animals (Swiss albino mice) of either sex were used for these experiments. The animals were housed in standard cages and were maintained on a standard pelleted feed (Guinea feed) and water ad libitum, after obtaining ethical committee approval. The present study was aimed to evaluate the anticonvulsant activity of TSBD derivative in mice.