The present study was aimed to estimate the hematologic and cytogenic effects of aplastic anemia induced by benzene. The study was performed on 90 female rats which divided into 2 groups, the 1st group was treated with benzene at dose of 1940 mg/kg orally for 15 days, while as 2nd group served as control (Placebo). Five male rats were taken randomly from each group and the complete blood picture, serum, serum IL-2 and cytogenic parameters were measured. The results revealed a significant decrease (P≥0.05) in the complete blood picture with significant increase (P≤0.05) in the serum IL-2 and all cytogenic parameters in treated group when compared with control group