Aqueous and alcoholic solvents mediated Zinc oxide/Magnesium oxide (ZnO-MgO) nanocomposites (denoted as ZOMONC’s) synthesized through co-precipitation process. The synthesized ZOMONC’s exhibited the formation of hexagonal and cubic crystal structure which is authenticated by powder X-ray study. The synthesized ZOMONC’s functional groups are scrutinized using FT-IR studies. Optical energy band gap and luminescence is identified by UV absorption and RT-PL studies. Spherical-like particles of various solvents mediated ZOMONC’s are observed from the SEM analysis. Mixture solvents mediated ZOMONC’s exhibited best in terms of size and morphology, which is subjected to TEM, Photocatalytic and antimicrobial studies. The synthesized ZOMONC’s is exhibited good photocatalytic activity against Amido black 10B dye. The antibacterial activity of the synthesized water-methanol solvent mediated ZOMONC’s sample against (a) Escherichia coli and (b) Staphylococcus aureus bacteria strain