Ventilator-associated pneumonia (VAP) is a common and serious complication in critically ill patients receiving mechanical ventilation in the intensive care unit (ICU). This review article aims to evaluate the impact of oral care protocols on VAP rates in ICU patients. A comprehensive literature search was conducted to identify relevant studies that investigated the effectiveness of oral care protocols in reducing the incidence of VAP. The findings suggest that proper oral care, including regular brushing, oral hygiene, and the use of antiseptic solutions, plays a crucial role in preventing VAP. Several studies have demonstrated a significant reduction in VAP rates with the implementation of structured oral care protocols. Factors such as the timing, frequency, and components of oral care protocols have been shown to influence their effectiveness in reducing VAP rates. Furthermore, the use of specialized oral care products and devices may offer additional benefits in preventing VAP in ICU patients. Overall, this review highlights the importance of implementing evidence-based oral care protocols as a key strategy to reduce VAP rates and improve patient outcomes in the ICU setting.