Cardiovascular disease (CVD) is the nation’s prevailing cause of mortality among men and women of all races. Purpose: This study aimed to determine the effect of cardiac rehabilitation program (CRP) on heart rate (HR), systolic and diastolic blood pressure (SBP and DBP), and exercise capacity (EC) in patients with CVD. Methods: This study was based on a two-arm parallel group randomized comparative design that included sixty-four participants (n=32/group) with CVD (mean age, 64.53±6.99 years) and was randomly allocated to two groups (CRP vs. Control). CRP Group received the CRP and home-based aerobic exercise program (AEP). The Control Group received the home-based AEP only. The outcomes, HR, SBP, DBP, and EC, were assessed using a sphygmomanometer and a six-minute walk test (6MWT). The t-test and Wilcoxon test were used to analyze between and within-group comparisons for all the outcomes scores, keeping the level of significance α at 95% (P<0.05) for all the statistical analyses. Results: The mean scores comparison of the outcomes, HR and 6MWT were found significant (95% CI, P<0.05) within CRP and Control groups; however, SBP and DBP mean scores were found insignificant (95% CI, P>0.05) within both groups, except DBP mean score which was found significant (P<0.05) within CRP Group. Comparing the outcomes mean scores between the groups at four-week post-intervention, HR, SBP, DBP, and 6MWT were found to be insignificant (P>0.05). Conclusions: The CRP and home-based AEP together and home-based AEP alone were equally effective in decreasing HR and improving EC in patients with CVD